AustralieFrV1, Main, Exploration, bibRecord, 002F64

DNAM-1 expression marks an alternative program of NK cell maturation.

Identifieur interne : 002F64 ( Main/Exploration ); précédent : 002F63; suivant : 002F65

DNAM-1 expression marks an alternative program of NK cell maturation.

Auteurs : Ludovic Martinet [France] ; Lucas Ferrari De Andrade [Brésil] ; Camille Guillerey [Australie] ; Jason S. Lee [Australie] ; Jing Liu [Australie] ; Fernando Souza-Fonseca-Guimaraes [Australie] ; Dana S. Hutchinson [Australie] ; Tatiana B. Kolesnik [Australie] ; Sandra E. Nicholson [Australie] ; Nicholas D. Huntington [Australie] ; Mark J. Smyth [Australie]

Source :

Cell reports [ 2211-1247 ] ; 2015.

RBID : pubmed:25818301

Descripteurs français

English descriptors

KwdEn :
- Adaptor Proteins, Signal Transducing (biosynthesis), Adaptor Proteins, Signal Transducing (metabolism), Antigens, Differentiation, T-Lymphocyte (biosynthesis), Antigens, Differentiation, T-Lymphocyte (genetics), Antigens, Differentiation, T-Lymphocyte (immunology), Cell Lineage (genetics), Cell Lineage (immunology), Cytokines (immunology), Cytokines (metabolism), Gene Expression Regulation, Humans, Interleukin-15 (immunology), Interleukin-15 (metabolism), Killer Cells, Natural (cytology), Killer Cells, Natural (metabolism), Signal Transduction.
MESH :
- chemical , biosynthesis : Adaptor Proteins, Signal Transducing, Antigens, Differentiation, T-Lymphocyte.
- chemical , genetics : Antigens, Differentiation, T-Lymphocyte.
- chemical , immunology : Antigens, Differentiation, T-Lymphocyte, Cytokines, Interleukin-15.
- chemical , metabolism : Adaptor Proteins, Signal Transducing, Cytokines, Interleukin-15.
- cytology : Killer Cells, Natural.
- genetics : Cell Lineage.
- immunology : Cell Lineage.
- metabolism : Killer Cells, Natural.
- Gene Expression Regulation, Humans, Signal Transduction.

Abstract

Natural killer (NK) cells comprise a heterogeneous population of cells important for pathogen defense and cancer surveillance. However, the functional significance of this diversity is not fully understood. Here, we demonstrate through transcriptional profiling and functional studies that the activating receptor DNAM-1 (CD226) identifies two distinct NK cell functional subsets: DNAM-1(+) and DNAM-1(-) NK cells. DNAM-1(+) NK cells produce high levels of inflammatory cytokines, have enhanced interleukin 15 signaling, and proliferate vigorously. By contrast, DNAM-1(-) NK cells that differentiate from DNAM-1(+) NK cells have greater expression of NK-cell-receptor-related genes and are higher producers of MIP1 chemokines. Collectively, our data reveal the existence of a functional program of NK cell maturation marked by DNAM-1 expression.

DOI: 10.1016/j.celrep.2015.03.006
PubMed: 25818301

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Natural killer (NK) cells comprise a heterogeneous population of cells important for pathogen defense and cancer surveillance. However, the functional significance of this diversity is not fully understood. Here, we demonstrate through transcriptional profiling and functional studies that the activating receptor DNAM-1 (CD226) identifies two distinct NK cell functional subsets: DNAM-1(+) and DNAM-1(-) NK cells. DNAM-1(+) NK cells produce high levels of inflammatory cytokines, have enhanced interleukin 15 signaling, and proliferate vigorously. By contrast, DNAM-1(-) NK cells that differentiate from DNAM-1(+) NK cells have greater expression of NK-cell-receptor-related genes and are higher producers of MIP1 chemokines. Collectively, our data reveal the existence of a functional program of NK cell maturation marked by DNAM-1 expression.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Brésil</li>
<li>France</li>
</country>
<region><li>Midi-Pyrénées</li>
<li>Occitanie (région administrative)</li>
<li>Victoria (État)</li>
</region>
<settlement><li>Melbourne</li>
</settlement>
<orgName><li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Martinet, Ludovic" sort="Martinet, Ludovic" uniqKey="Martinet L" first="Ludovic" last="Martinet">Ludovic Martinet</name>
</region>
</country>
<country name="Brésil"><noRegion><name sortKey="Ferrari De Andrade, Lucas" sort="Ferrari De Andrade, Lucas" uniqKey="Ferrari De Andrade L" first="Lucas" last="Ferrari De Andrade">Lucas Ferrari De Andrade</name>
</noRegion>
</country>
<country name="Australie"><noRegion><name sortKey="Guillerey, Camille" sort="Guillerey, Camille" uniqKey="Guillerey C" first="Camille" last="Guillerey">Camille Guillerey</name>
</noRegion>
<name sortKey="Huntington, Nicholas D" sort="Huntington, Nicholas D" uniqKey="Huntington N" first="Nicholas D" last="Huntington">Nicholas D. Huntington</name>
<name sortKey="Hutchinson, Dana S" sort="Hutchinson, Dana S" uniqKey="Hutchinson D" first="Dana S" last="Hutchinson">Dana S. Hutchinson</name>
<name sortKey="Kolesnik, Tatiana B" sort="Kolesnik, Tatiana B" uniqKey="Kolesnik T" first="Tatiana B" last="Kolesnik">Tatiana B. Kolesnik</name>
<name sortKey="Lee, Jason S" sort="Lee, Jason S" uniqKey="Lee J" first="Jason S" last="Lee">Jason S. Lee</name>
<name sortKey="Liu, Jing" sort="Liu, Jing" uniqKey="Liu J" first="Jing" last="Liu">Jing Liu</name>
<name sortKey="Nicholson, Sandra E" sort="Nicholson, Sandra E" uniqKey="Nicholson S" first="Sandra E" last="Nicholson">Sandra E. Nicholson</name>
<name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J" last="Smyth">Mark J. Smyth</name>
<name sortKey="Souza Fonseca Guimaraes, Fernando" sort="Souza Fonseca Guimaraes, Fernando" uniqKey="Souza Fonseca Guimaraes F" first="Fernando" last="Souza-Fonseca-Guimaraes">Fernando Souza-Fonseca-Guimaraes</name>
</country>
</tree>
</affiliations>
</record>

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DNAM-1 expression marks an alternative program of NK cell maturation.

DNAM-1 expression marks an alternative program of NK cell maturation.

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